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Year : 2014  |  Volume : 5  |  Issue : 3  |  Page : 96-100

Prevalence of red cell allo-antibodies among muti-transfused autoimmune hemolytic anemia Egyptian patients

Department of Clinical Pathology, Ain Shams University, Cairo, Egypt

Correspondence Address:
Hanan Mohamed Mahmoud
Department of Clinical Pathology, Ain Shams University, Eldemerdash Hospital, Ramsis Street, Cairo
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1658-5127.141996

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Background: The aim is to detect the prevalence and specificity of red cell allo-antibodies underlying pan reactive auto-antibodies in Egyptian AIHA patients Patients and Methods: Sixty multi-transfused Egyptian AIHA patients received 715 units of blood were studied during the period from February 2013 to November 2013. Initial antibody screening and identification (using pre-warming technique in cases of cold auto-antibodies), direct antiglobulin, auto-control and immediate spin, allogenic adsorption for patients` plasma then detection of possible underlying allo-antibodies were done. Results: Five patients with cold auto-antibodies were identified with absence of underlying allo-antibodies. From the 55 patients with warm auto-antibodies, 23 (41.8%) had allo-antibodies with a total number of 40 underlying allo-antibodies indicating that Egyptians carry the highest percentage of allo-antibodies compared to other studies. Conclusion: Red cell allo-immunization has a very high frequency among multi-transfused Egyptian AIHA patients.

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