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Year : 2018  |  Volume : 9  |  Issue : 2  |  Page : 77

May–Hegglin anomaly

1 Hematology Laboratory Section of Medical Laboratory Department, Qatif Central Hospital, MOH, Saudi Arabia
2 Department of Internal Medicine, Qatif Central Hospital, MOH, Saudi Arabia

Date of Web Publication18-Jun-2018

Correspondence Address:
Dr. Mona Alfaraj
Qatif Central Hospital, Ministry of Health, 7462-Al Jamiymah, Al Qatif 32662-3201
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/joah.joah_25_18

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How to cite this article:
Alfaraj M, Al-Hadad F. May–Hegglin anomaly. J Appl Hematol 2018;9:77

How to cite this URL:
Alfaraj M, Al-Hadad F. May–Hegglin anomaly. J Appl Hematol [serial online] 2018 [cited 2023 Feb 3];9:77. Available from: https://www.jahjournal.org/text.asp?2018/9/2/77/234552

A 27-year-old male presented to emergency room with a finger pain postminor trauma. On examination, he had signs of local inflammation with no fever, no pallor, no evidence of bleeding, and no organomegaly. Complete blood count was normal except of low platelets (62 × 103/uL), and mean platelet volume was not recorded. Peripheral blood smear (PBS) demonstrated Dohle-like bodies in the neutrophils and megathrombocytes which are findings of May–Hegglin anomaly (MHA). The abnormal large platelets underestimated actual platelet count which was suggested to be higher by PBS. The estimated platelet count was 95 × 103/uL. The patient gave a positive family history of MHA in his mother. One-month postlocal treatment, a repeated PBS showed similar findings [Figure 1].
Figure 1: Large platelets (a) and neutrophil with Dohle-like body inclusion (b) in the first and subsequent posttreatment (c) peripheral blood smears of the patient

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MHA is one of the autosomal dominant macrothrombocytopenias.[1],[2] These disorders including Sebastian syndrome, Fechtner syndrome, and Epstein syndrome are clinically variable.[1] It is associated with Dohle-like bodies and macrothrombocytopenia secondary to defective megakaryocytic maturation due to mutation in MYH9 gene in chromosome 22q12-13.[1],[2] Most MHA patients have mild bleeding tendency, depending on the degree of thrombocytopenia.[1],[2] The importance of such case is to emphasize the importance of PBS examination when false reading on automated cell counter was given by megathrombocytes.[1]

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

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Conflicts of interest

There are no conflicts of interest.

  References Top

Hsia CC, Xenocostas A. May-hegglin anomaly. Blood 2012;119:328.  Back to cited text no. 1
Fatima S. May hegglin anomaly: Rare entity with review of literature. Indian J Hematol Blood Transfus 2012;28:58-60.  Back to cited text no. 2


  [Figure 1]


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