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Year : 2019  |  Volume : 10  |  Issue : 4  |  Page : 149-153

Diagnostic challenges of de novo acute leukemia with positive BCR-ABL1 fusion: Case report and review of literature

Department of Pathology, College of Medicine, Jouf University, Sakaka, S, audi Arabia

Correspondence Address:
Dr. Abdulrahman Hamdan Almaeen
P.O. Box: 2014, Sakaka, Aljouf
audi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/joah.joah_68_19

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A 32-year-old female was admitted because of an acute course of gum bleeding and fatigability. On complete blood cell counts, bicytopenia was evident. Morphologic evaluation of the peripheral blood smear and bone marrow materials revealed remarkable involvement by two separate blastic populations (myeloid/B-cell lymphoid). Karyotyping, fluorescence in situ hybridization, and molecular analysis showed positive Philadelphia chromosome and BCR-ABL1 (p210) fusion. chronic myeloid leukemia in blast phase (CML-BP) versus mixed phenotype acute leukemia was critically debated as to which the final diagnosis should be assigned.

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