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Year : 2021  |  Volume : 12  |  Issue : 4  |  Page : 217-219

Immature granulocyte percentage in early chronic myeloid leukemia

1 Department of Pathology, Baptist Christian Hospital, Tezpur, Assam, India
2 Department of Internal Medicine, Baptist Christian Hospital, Tezpur, Assam, India

Correspondence Address:
Dr. Mahendra Narain Mishra
Baptist Christian Hospital, Tezpur - 784 001, Assam
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/joah.joah_4_21

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A 38-year-old man presented with mild fatigue of recent onset to the medical outpatient department (OPD). Clinical examination showed an absence of fever, pallor, and no organomegaly. Routine complete blood count (CBC) showed mild leukocytosis (total leukocyte count 22.93 × 109/L), absence of features of sepsis but with immature granulocyte (IG) fraction of 26.6% on peripheral blood film without basophilia or eosinophilia. A diagnosis of chronic myeloid leukemia (CML) was suspected which was confirmed by conventional karyotyping and quantitative reverse transcription − polymerase chain reaction (QPCR). Following administration of imatinib for 2 weeks, a follow-up CBC showed a reduction in IG fraction to 1.5%. The patient is under follow-up in OPD for 4 months and is responding well as substantiated by follow-up QPCR. To the best of our knowledge, this is the first ever report where CML was first suspected on the basis of IG fraction and the same parameter proved useful for follow-up.

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