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CASE REPORT
Year : 2022  |  Volume : 13  |  Issue : 3  |  Page : 157-161

Transfusion-dependent anemia, and cytopenia secondary to parvovirus B19 infection as the first manifestation of X-linked hyper immunoglobulin M immunodeficiency syndrome in two male patients in their third decade of life


1 Princess Noorah Oncology Center, Dr. Soliman Fakeeh Hospital, Jeddah, Saudi Arabia
2 Princess Noorah Oncology Center, Jeddah, Saudi Arabia

Correspondence Address:
Dr. Hadel El-Haddad
Princess Noorah Oncology Center, Dr. Soliman Fakeeh Hospital, Jeddah
Saudi Arabia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/joah.joah_179_21

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We describe two male patients with unique mutation of the CD40L gene, unlike the classic presentation of X-linked hyper immunoglobulin M immunodeficiency syndrome (XHIGM syndrome), both were healthy until presenting in their early twenties with a challenging symptomatic transfusion-dependent anemia, investigations confirmed XHIGM syndrome with concurrent chronic parvovirus infection.


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