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IMAGE IN HEMATOLOGY
Year : 2023  |  Volume : 14  |  Issue : 1  |  Page : 70

A rare form of acute myeloid leukemia


Centre Hospitalier Agen-Nerac, Laboratoire de Biologie Medicale, Saint-Esprit, Agen, France

Date of Submission14-Oct-2022
Date of Acceptance30-Nov-2022
Date of Web Publication17-Feb-2023

Correspondence Address:
Dr. Nicolas Athanase
Centre Hospitalier Agen-Nérac, Laboratoire De Biologie Médicale, Route de Villeneuve Sur Lot, Saint-Esprit, 47923 Agen
France
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/joah.joah_90_22

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How to cite this article:
Athanase N. A rare form of acute myeloid leukemia. J Appl Hematol 2023;14:70

How to cite this URL:
Athanase N. A rare form of acute myeloid leukemia. J Appl Hematol [serial online] 2023 [cited 2023 Mar 20];14:70. Available from: https://www.jahjournal.org/text.asp?2023/14/1/70/369848

An 82-year-old man was admitted in the hematology department for an incidentally found bicytopenia after a cure of inguinofemoral hernia. Since the operation, the patient described dyspnea on exertion due to minimum effort without any symptoms of infection, weight loss, or chest pain. At the admission, the patient suffered from asthenia and dyspnea on making the smallest of efforts. A complete blood count showed: hemoglobin – 4.9 g/dL; platelets – 7 × 109/L; white blood count – 3.9 × 109/L; and neutrophils – 2.8 × 109/L with normal ferritin and B9/B12 vitamins. Bone marrow smear examination revealed the presence of proerythroblast-like blasts cells (45%) with a round nuclei, fine chromatin, and highly basophilic cytoplasm with cytoplasmic expansions ([Figure 1]a and [Figure 1]b, original magnification × 1000, May-Grünwald Giemsa staining). No dysplasia was observed. Blasts immunophenotyping showed the expression of erythroid markers CD36, CD71, and CD235a. Megakaryoblastic and monoblastic markers such as CD41, CD61, CD11b, CD14, and CD64 were negative. Karyotype was complex with no specific genetic abnormalities. Molecular analysis was normal. The diagnosis of pure erythroid leukemia was retained according to the WHO 2016 criteria. Unfortunately, the patient refused AZACITIDINE chemotherapy and was lost to follow-up. Pure erythroid leukemia is extremely rare, and such blasts should not be confused with benign proerythroblasts.
Figure 1: (a-b) Proerythroblast-like blasts cells using May-Grünwald Giemsa staining. Original magnification x 1000

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Acknowledgments

Nicolas Athanase collected data, analyzed data, and wrote paper; Elise Frebet analyzed data and reviewed manuscript.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.




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