|IMAGE IN HEMATOLOGY
|Year : 2023 | Volume
| Issue : 1 | Page : 70
A rare form of acute myeloid leukemia
Centre Hospitalier Agen-Nerac, Laboratoire de Biologie Medicale, Saint-Esprit, Agen, France
|Date of Submission||14-Oct-2022|
|Date of Acceptance||30-Nov-2022|
|Date of Web Publication||17-Feb-2023|
Dr. Nicolas Athanase
Centre Hospitalier Agen-Nérac, Laboratoire De Biologie Médicale, Route de Villeneuve Sur Lot, Saint-Esprit, 47923 Agen
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Athanase N. A rare form of acute myeloid leukemia. J Appl Hematol 2023;14:70
An 82-year-old man was admitted in the hematology department for an incidentally found bicytopenia after a cure of inguinofemoral hernia. Since the operation, the patient described dyspnea on exertion due to minimum effort without any symptoms of infection, weight loss, or chest pain. At the admission, the patient suffered from asthenia and dyspnea on making the smallest of efforts. A complete blood count showed: hemoglobin – 4.9 g/dL; platelets – 7 × 109/L; white blood count – 3.9 × 109/L; and neutrophils – 2.8 × 109/L with normal ferritin and B9/B12 vitamins. Bone marrow smear examination revealed the presence of proerythroblast-like blasts cells (45%) with a round nuclei, fine chromatin, and highly basophilic cytoplasm with cytoplasmic expansions ([Figure 1]a and [Figure 1]b, original magnification × 1000, May-Grünwald Giemsa staining). No dysplasia was observed. Blasts immunophenotyping showed the expression of erythroid markers CD36, CD71, and CD235a. Megakaryoblastic and monoblastic markers such as CD41, CD61, CD11b, CD14, and CD64 were negative. Karyotype was complex with no specific genetic abnormalities. Molecular analysis was normal. The diagnosis of pure erythroid leukemia was retained according to the WHO 2016 criteria. Unfortunately, the patient refused AZACITIDINE chemotherapy and was lost to follow-up. Pure erythroid leukemia is extremely rare, and such blasts should not be confused with benign proerythroblasts.
|Figure 1: (a-b) Proerythroblast-like blasts cells using May-Grünwald Giemsa staining. Original magnification x 1000|
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Nicolas Athanase collected data, analyzed data, and wrote paper; Elise Frebet analyzed data and reviewed manuscript.
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Conflicts of interest
There are no conflicts of interest.