Year : 2022 | Volume
: 13 | Issue : 1 | Page : 1--4
Delta beta thalassemia, a rare hemoglobin variant: An experience from nodal centre in North Indian state
Promil Jain, Nisha Marwah, Niti Dalal, Richa Pawar, Meenu Gill, Sanjay Kumar
Department of Pathology, Pt. B. D. Sharma, PGIMS, Rohtak, Haryana, India
CONTEXT: Fetal hemoglobin (HbF) reduces to <1% few months after birth. However, it can persist beyond infancy into adult life in rare conditions such as delta-beta (δβ) thalassemia and hereditary persistence of HbF. δβ thalassemia is a relatively rare type of thalassemia due to decrease in both beta and delta globin chain production.
AIMS: This study aims to assess the hematological and high-performance liquid chromatography (HPLC) findings in δβ thalassemia.
SETTINGS AND DESIGN: Cross-sectional observational study.
SUBJECTS AND METHODS: The study was conducted in department of Clinical Pathology, PGIMS, Rohtak. On screening of 1197 patients over a period of around 1 year, a total of 13 cases of δβ thalassemia were detected by HPLC.
STATISTICAL ANALYSIS USED: Not done.
RESULTS: The age of presentation ranged from 1 to 42 years with a mean age of 22.8 years. Eleven cases were diagnosed as heterozygous δβ thalassemia and two as homozygous δβ thalassemia.
CONCLUSIONS: δβ thalassemia is an uncommon cause of elevated HbF. Clinical and hematological parameters should be carefully analyzed for accurate diagnosis.
Dr. Niti Dalal
Department of Pathology, Pt. B. D. Sharma, PGIMS, Rohtak, Haryana
|How to cite this article:|
Jain P, Marwah N, Dalal N, Pawar R, Gill M, Kumar S. Delta beta thalassemia, a rare hemoglobin variant: An experience from nodal centre in North Indian state.J Appl Hematol 2022;13:1-4
|How to cite this URL:|
Jain P, Marwah N, Dalal N, Pawar R, Gill M, Kumar S. Delta beta thalassemia, a rare hemoglobin variant: An experience from nodal centre in North Indian state. J Appl Hematol [serial online] 2022 [cited 2022 Jun 26 ];13:1-4
Available from: https://www.jahjournal.org/article.asp?issn=1658-5127;year=2022;volume=13;issue=1;spage=1;epage=4;aulast=Jain;type=0