Journal of Applied Hematology

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 13  |  Issue : 3  |  Page : 126--131

Evaluation of tyrosine kinase inhibitor discontinuation initiative in patients with chronic myeloid leukemia at princess noorah oncology center


Afnan Mohammed Noor1, Mansoor Ahmed Khan1, Muteb M Al-Thomali2, Abdelmajid H Alnatsheh1, Ahmed A Absi2, Fahad M Hakami3, Majed A Alshamrani1 
1 Department of Pharmaeceutical Care, Ministry of National Guard-Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia
2 Department of Haematology, Ministry of National Guard-Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia
3 Department of Molecular Medicine, Ministry of National Guard-Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia

Correspondence Address:
Dr. Mansoor Ahmed Khan
Department of Pharmaceutical Care, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, P. O. Box: 9515, Jeddah 21423
Saudi Arabia

CONTEXT: Tyrosine kinase inhibitors (TKIs) are the standard of care therapy for chronic myeloid leukemia (CML). The current disadvantages of lifelong treatment include adverse effects and financial burden. AIMS: This study aimed to evaluate the outcomes of treatment-free remission (TFR) in CML patients. SETTINGS AND DESIGN: A retrospective cohort study was conducted in our oncology center. SUBJECTS AND METHODS: Patients ≥18 years old diagnosed with CML, received TKI and had a TFR trial to achieve TFR, with at least 6 months follow-up, and who received TKIs were included. Patients with a previous hematopoietic stem cell transplantation were excluded. The primary outcome was the proportion of patients with sustainable TFR at 6 months. The secondary outcomes were the proportion of patients with sustainable TFR at 12 months, the rate of regaining a major molecular response (MMR) after relapse, and the cost-saving impact. Descriptive statistics were used for the demographics and outcomes. RESULTS: A total of 250 patients were screened for eligibility, 25 patients were enrolled. The median age was 54 years (interquartile range: 45.5–59), 60% were female. TFR was 92% at 6 months and 72% at 12 months. 100% of the patients regained MMR. The total number of TFR days were 17,024 which resulted in a direct cost saving of SR 7,205,601.9, based on Saudi FDA pricing. CONCLUSIONS: The study indicated that the majority of the CML patients achieved 6 months TFR. This initiative has resulted in a significant cost saving. Future studies should characterize potential candidates for TKI discontinuation.


How to cite this article:
Noor AM, Khan MA, Al-Thomali MM, Alnatsheh AH, Absi AA, Hakami FM, Alshamrani MA. Evaluation of tyrosine kinase inhibitor discontinuation initiative in patients with chronic myeloid leukemia at princess noorah oncology center.J Appl Hematol 2022;13:126-131


How to cite this URL:
Noor AM, Khan MA, Al-Thomali MM, Alnatsheh AH, Absi AA, Hakami FM, Alshamrani MA. Evaluation of tyrosine kinase inhibitor discontinuation initiative in patients with chronic myeloid leukemia at princess noorah oncology center. J Appl Hematol [serial online] 2022 [cited 2022 Oct 6 ];13:126-131
Available from: https://www.jahjournal.org/article.asp?issn=1658-5127;year=2022;volume=13;issue=3;spage=126;epage=131;aulast=Noor;type=0